Oral and Intraperitoneal Acute Toxicity Studies of Sesamum radiatum Aqueous Leaf Extract in Female Wistar Rats

Background and aims: Sesamum radiatum leaves are commonly used by African Ivorian people in particular to treat various diseases. However, few studies have been done on the pharmacological properties even less acute toxicity of this medicinal plant Côte d'Ivoire. Also, present work was carried out order contribute correcting through a comparative study oral intraperitoneal aqueous extract (ESera) female Wistar rat.
 Méthodes: According modified OECD 423 method, 2 groups 6 rats were treated with ESera at 50 mg/kg 2000 single dose respectively administration comparison control group (NaCl 0.9 %). Dice weighing regular intervals days body weight removal some organs blood samples end 14-day observation period allowed measurement biological parameters.
 Results: Irrespective route, did not cause clinical signs suffering, behavior change death rats. The morphology relative (heart, kidneys, liver lungs) modified. Treated animals exhibited growth kinetics similar those controls. Greater gains (p < 0.05) obtained ESera. showed statistically significant changes certain hematological serum biochemical parameters. observed greater administration.
 Conclusion: or organ during 14 observation.However, better determine its toxicity, other must be due disturbances parameters, transaminases electrolytes.
 Keywords: Acute Hematological Biochemical Organ biometry